GGTI-286 hydrochloride | GGTase I inhibitor | Probechem Biochemicals

Chemical Structure : GGTI-286 hydrochloride

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GGTI-286 hydrochloride (GGTI286)

货号: PC-62473Not For Human Use, Lab Use Only.

GGTI-286 hydrochloride is a CAAX peptidomimetic that is a potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277.

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生物&药学活性

GGTI-286 hydrochloride is a CAAX peptidomimetic that is a potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277.
GGTI-286 inhibits processing of the geranylgeranylated protein Rap1A.
GGTI-286 inhibits oncogenic K-Ras4B stimulation with IC50 of 1 uM.
GGTI-286 reduces nuclear localization of β-catenin and transcription dependent on β-catenin/T cell factor in mammalian cells.
GGTI-286 has significant antiproliferative effect in human malignant glioma cells.

物理化学性质&存储条件

分子量	466.037
分子式	C23H32ClN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylpentanoate hydrochloride

参考文献

1. Lerner EC, et al. J Biol Chem. 1995 Nov 10;270(45):26770-3.

2. Nishiya N, et al. Chem Biol. 2014 Apr 24;21(4):530-40.

3. Lerner EC, et al. Oncogene. 1997 Sep;15(11):1283-8.

GGTI-286 hydrochloride (GGTI286)

生物&药学活性

物理化学性质&存储条件

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GGTI-286 hydrochloride (GGTI286)

生物&药学活性

物理化学性质&存储条件

参考文献

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