SPL-707 |CAS: 2195361-33-0 Probechem Biochemicals

Chemical Structure : SPL-707

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SPL-707 (SPL707)

货号: PC-62535Not For Human Use, Lab Use Only.

SPL-707 (SPL707) is the first selective, orally active signal peptide peptidase-like 2a (SPPL2a) inhibitor with IC50 of 77 nM, shows 25-fold selectivity over γ-secretase and SPP.

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生物&药学活性

SPL-707 (SPL707) is the first selective, orally active signal peptide peptidase-like 2a (SPPL2a) inhibitor with IC50 of 77 nM, shows 25-fold selectivity over γ-secretase and SPP.
SPL-707 significantly inhibits processing of the SPPL2a substrate CD74/p8 fragment in rodents at doses ≤10 mg/kg b.i.d. po., recapitulates the phenotype seen in Sppl2a knockout (ko) and ENU mutant mice after oral dosing of 40 for 11 days at ≥10 mg/kg b.i.d.

物理化学性质&存储条件

分子量	505.55
分子式	C27H28FN5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-cyclopropyl-N1-((S)-5,11-dioxo-10,11-dihydro-1H,3H,5H-spiro[benzo[d]pyrazolo[1,2-a][1,2]diazepine-2,1'-cyclopropan]-10-yl)-N4-(5-fluoro-2-methylpyridin-3-yl)succinamide

参考文献

1. Velcicky J, et al. J Med Chem. 2018 Feb 8;61(3):865-880.

SPL-707 (SPL707)

生物&药学活性

物理化学性质&存储条件

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SPL-707 (SPL707)

生物&药学活性

物理化学性质&存储条件

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