| Cat. No. |
Product Name |
Information |
| PC-49561 |
NTE-122
ACAT inhibitor
|
NTE-122 (NTE122) is a potent selective and competitive acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, inhibits microsomal ACAT activities of various tissues and cultured cells (HepG2 and CaCo-2), with IC50 values from 1.2 to 9.6 nM. |
| PC-49557 |
FR054
PGM3 inhibitor
|
FR054 (FR-054) is a specific small molecule inhibitor of hexosamine biosynthetic pathway (HBP) enzyme N-Acetylglucosamine-phosphate Mutase (PGM3), shows a remarkable anti-breast cancer effect. |
| PC-49548 |
DS55980254
PTDSS1 inhibitor
|
DS55980254 (DS 55980254) is potent, selective and orally active PTDSS1 (phosphatidylserine synthetase 1) inhibitor, suppresses phosphatidylserine (PS) production activity of PTDSS1 (IC50=100 nM) in cell-free assays, but not that of PTDSS2. |
| PC-49527 |
SEN177
Glutaminyl cyclase inhibitor
|
SEN177 (SEN-177) is a highly potent human glutaminyl cyclase (hQC) inhibitor Ki value of 20 nM. |
| PC-49511 |
Tryptolinamide
PFK1 inhibitor
|
Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive and F6P-competitive manner (Ki=5.0 uM). |
| PC-49503 |
LMTK3 inhibitor C36
LMTK3 inhibitor
|
LMTK3 inhibitor C36 is a highly selective, ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) with IC50 of 100 nM in in vitro kinase assays and MST binding Kd of 1.87 uM. |
| PC-49470 |
MO-I-1182
ASPH inhibitor
|
MO-I-1182 is a small molecule inhibitor of aspartate beta-hydroxylase (ASPH), suppresses cholangiocarcinoma metastasis. |
| PC-49460 |
CLOCK inhibitor CLK8
CLOCK inhibitor
|
CLOCK inhibitor CLK8 is a CLOCK-binding small molecule disrupting the interaction between CLOCK and BMAL1, interferes with nuclear translocation of CLOCK both in vivo and in vitro. |
| PC-49459 |
TH301
CRY2 stabilizer
|
TH301 (TH 301) is a isoform-selective small molecule stabilizer of Cryptochrome 2 (CRY2). |
| PC-49458 |
KL101
CRY1 stabilizer
|
KL101 (KL 101) is a isoform-selective small molecule stabilizer of Cryptochrome 1 (CRY1). |
| PC-49457 |
PGP inhibitor CP1
PGP inhibitor
|
PGP inhibitor CP1 is a specific small-molecule phosphoglycolate phosphatase (PGP) inhibitor with IC50 of 0.39 uM (hPGP), blocks PGP-dependent glycolytic flux in mammalian cells. |
| PC-49456 |
CRY1 destabilizer M47
CRY1 destabilizer
|
CRY1 destabilizer M47 is a selective small molecule that destabilizes Cryptochrome 1 (CRY1) both in vitro and in vivo, binds to the primary pocket in the PHR domain and specifically destabilizes CRY1 by enhancing its ubiquitination. |
