AR9281 | sEH inhibitor | Probechem Biochemicals

Chemical Structure : AR9281

CAS No.: 913548-29-5

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AR9281 (AR 9281, APAU)

货号: PC-21824Not For Human Use, Lab Use Only.

AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (sEH) inhibitor with IC50 of 8 nM and 3 nM for human and mouse sEH enzyme, respectively.

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10 mg	￥1580	In stock
25 mg	￥2780	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (sEH) inhibitor with IC50 of 8 nM and 3 nM for human and mouse sEH enzyme, respectively.
AR9281 is highly selective with no inhibitory activity against microsomal epoxide hydrolase or an extended panel of ca.150 other enzyme and receptor targets at 10 uM.
AR9281 attenuates the enhanced glucose excursion following an intraperitoneal glucose tolerance test in mouse model of diet induced obesity.
AR9281 also attenuates the increase in blood pressure in angiotensin-II-induced hypertension in rats.

物理化学性质&存储条件

分子量	319.45
分子式	C18H29N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea

参考文献

1. Anandan SK, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):983-8.

2. Zhang LN, et al. Eur J Pharmacol. 2011 Mar 1;654(1):68-74.

AR9281 (AR 9281, APAU)

生物&药学活性

物理化学性质&存储条件

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AR9281 (AR 9281, APAU)

生物&药学活性

物理化学性质&存储条件

参考文献

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