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首页-小分子抑制剂&激动剂-Others-Other Targets-BRD1732
BRD1732

Chemical Structure : BRD1732

CAS No.:

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BRD1732 (BRD 1732)

货号: PC-21989Not For Human Use, Lab Use Only.

BRD1732 is an ubiquitinated bifunctional small molecule that could be directly ubiquitinated in cells, resulting in dramatic accumulation of inactive ubiquitin monomers and polyubiquitin chains causing broad inhibition of the ubiquitin-proteasome system.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BRD1732 is an ubiquitinated bifunctional small molecule that could be directly ubiquitinated in cells, resulting in dramatic accumulation of inactive ubiquitin monomers and polyubiquitin chains causing broad inhibition of the ubiquitin-proteasome system.
    Ubiquitination of BRD1732 and its associated cytotoxicity are stereospecific and dependent upon two homologous E3 ubiquitin ligases, RNF19A and RNF19B.

    物理化学性质&存储条件

    分子量 404.49
    分子式 C25H25FN2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(((2S,3R,4R)-3-([1,1'-biphenyl]-4-yl)-4-(hydroxymethyl)azetidin-2-yl)methyl)-3-fluoro-N-methylbenzamide

    参考文献

    1. Li W, et al. bioRxiv [Preprint]. 2024 Jan 28:2024.01.26.577493.

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