IDE397 (GSK4362676, GSK-676) | MAT2A inhibitor | Probechem Biochemicals

Chemical Structure : IDE397

CAS No.: 2439277-80-0

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IDE397 (GSK4362676, GSK-676, IDE-397)

货号: PC-21894Not For Human Use, Lab Use Only.

IDE397 (GSK4362676, GSK-676, IDE397) is a potent, selective small molecule methionine adenosyltransferase 2a (MAT2A) inhibitor, displays broad anti-tumor activity across a panel of MTAP-deleted patient-derived xenografts.

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生物&药学活性

IDE397 (GSK4362676, GSK-676, IDE397) is a potent, selective small molecule methionine adenosyltransferase 2a (MAT2A) inhibitor, displays broad anti-tumor activity across a panel of MTAP-deleted patient-derived xenografts.
IDE397 produces a dose- and time-dependent modulation of the proximal and distal PD biomarkers SAM and symmetrically di-methylates arginine (SDMA) in HCT116 MTAP-deleted CDX model.
HCT116 MTAP-deleted CDX model is more sensitive to IDE397 compared to the HCT116 MTAP-WT model.
IDE397 displays broad anti-tumor activity across a panel of MTAP-deleted patient-derived xenografts. exhibits anti-tumor activity as a single agent in MTAP-deleted CDX models and in MTAP-deleted PDX models of NSCLC, pancreatic, bladder, head and neck, esophageal and gastric cancer.

物理化学性质&存储条件

分子量	340.69
分子式	C14H8ClF3N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-amino-1-(2-chlorophenyl)-7-(trifluoromethyl)-

参考文献

1. Marcus M. Fischer, et al. Cancer Res (2021) 81 (13_Supplement): 1278.

IDE397 (GSK4362676, GSK-676, IDE-397)

生物&药学活性

物理化学性质&存储条件

参考文献

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IDE397 (GSK4362676, GSK-676, IDE-397)

生物&药学活性

物理化学性质&存储条件

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