MIF agonist MIF20 | MIF agonist | Probechem Biochemicals

Chemical Structure : MIF agonist MIF20

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MIF agonist MIF20 (MIF20)

货号: PC-21876Not For Human Use, Lab Use Only.

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生物&药学活性

MIF agonist MIF20 is an allosteric small molecule agonist of macrophage migration inhibitory factor (MIF), binds to MIF and increases its affinity for the cognate MIF receptor CD74, increasing the strength of downstream signal transduction.
MIF20 reduces infarct size and preserves cardiac systolic function caused by I/R.
MIF20 attenuates IR-induced cardiac fibrosis in aging. MIF20 improves the contractile properties of isolated cardiomyocytes under stress.
MIF20 preserves mitochondrial respiratory fitness via energy metabolism and maintainenance of redox homeostasis under pathological stress.
MIF20 modulates the NAD+/ NADH and metabolic homeostasis under I/R.
MIF20 enhances the MIF-CD74/CD44-AMPK signaling cascade to increase cardiac glucose uptake and exert a cardioprotection action against I/R injury in vivo.

物理化学性质&存储条件

分子量	238.25
分子式	C13H10N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(pyridine-3-yl)-1H-1,2,3-triazole-1-yl) phenol

参考文献

1. Hao Wang, et al. Metabolism. 2024 Jan 15:153:155792.

MIF agonist MIF20 (MIF20)

生物&药学活性

物理化学性质&存储条件

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MIF agonist MIF20 (MIF20)

生物&药学活性

物理化学性质&存储条件

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