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Miglustat

Chemical Structure : Miglustat

CAS No.: 72599-27-0

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Miglustat (N-Butyldeoxynojirimycin, SC-48334, NB-DNJ, OGT-918)

货号: PC-45141Not For Human Use, Lab Use Only.

Miglustat (N-Butyldeoxynojirimycin, SC-48334, NB-DNJ, OGT-918) is an orally active and reversible inhibitor of glucosylceramide synthase (GCS, ceramide glucosyltransferase).

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Miglustat (N-Butyldeoxynojirimycin, SC-48334, NB-DNJ, OGT-918) is an orally active and reversible inhibitor of glucosylceramide synthase (GCS, ceramide glucosyltransferase).
Miglustat inhibits glycolipid biosynthesis, has no effect on the maturation of N-linked oligosaccharides or on lysosomal glucocerebrosidase.
Miglustat is used primarily to treat type I Gaucher disease (GD1).

物理化学性质&存储条件

分子量 219.278
分子式 C10H21NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, (2R,3R,4R,5S)-

参考文献

1. Platt FM, et al. J Biol Chem. 1994 Oct 28;269(43):27108-14.

2. D'Arcangelo G, et al. Neural Plast. 2016;2016:3830424.

3. Fischer PB, et al. J Virol. 1995 Sep;69(9):5791-7.

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