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首页-小分子抑制剂&激动剂-Others-Other Targets-BDM35899
BDM35899

Chemical Structure : BDM35899

CAS No.: 2785377-42-4

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BDM35899

货号: PC-26432Not For Human Use, Lab Use Only.

BDM35899 is a small activator of insulin degrading enzyme (IDE) with pEC50 of 5.3, binds to polyanion-binding site of IDE, activates both Aβ and insulin hydrolysis by IDE, decreases glucose-stimulating insulin secretion in β-pancreatic cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BDM35899 is a small activator of insulin degrading enzyme (IDE) with pEC50 of 5.3, binds to polyanion-binding site of IDE, activates both Aβ and insulin hydrolysis by IDE, decreases glucose-stimulating insulin secretion in β-pancreatic cells.

物理化学性质&存储条件

分子量 456.58
分子式 C22H24N4O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[1-(thiophene-2-sulfonyl)-1H-indol-3-yl]-N-(3-imidazole-1-yl-propyl)-butyramide

参考文献

1. Nicolas Kraupner, et al. Eur J Med Chem. 2022 Jan 15:228:113982.

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