APE1 inhibitor C10 | APE1 inhibitor | Probechem Biochemicals

Chemical Structure : APE1 inhibitor C10

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APE1 inhibitor C10 (Refi-10)

货号: PC-26426Not For Human Use, Lab Use Only.

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生物&药学活性

APE1 inhibitor C10 (Refi-10) is a specific small molecule inhibitor of redox activity of APE1 with binding affinity (SPR Kd) of 189 nM, inhibits the redox function, but not the DNA repair function of APE1.
C10 blocks AP-1 DNA binding activity with IC50 of 17 uM in EMSA assays.
C10 inhibits KSHV lytic replication through blocking AP-1 signaling and RTA expression, inhibits intracellular DNA and extracellular virion with IC50 and EC50 of 4.6 uM and 0.16 uM respectively.
C10 (10 uM) inhibits KSHV-induced angiogenesis of oral mesenchymal stem cells (MSCs), inhibits KSHV-mediated secretion of angiogenic growth factors VEGF-A, IL-6 and IL-8 from PDLSCs.

物理化学性质&存储条件

分子量	284.31
分子式	C17H16O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1E,6E)-1,7-bis(5-methylfuran-2-yl)hepta-1,6-diene-3,5-dione

参考文献

1. Canrong Zhong, et al. PLoS Pathog. 2017 Apr 5;13(4):e1006289.

2. Yan C, et al. Invest Ophthalmol Vis Sci. 2026 Mar 2;67(3):47.

APE1 inhibitor C10 (Refi-10)

生物&药学活性

物理化学性质&存储条件

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APE1 inhibitor C10 (Refi-10)

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物理化学性质&存储条件

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