NBDHEX

Chemical Structure : NBDHEX

CAS No.: 787634-60-0

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货号: PC-26377Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

NBDHEX is a potent glutathione S-transferase (GST) inhibitor, inhibits human glutathione S-transferases GSTA1-1, GSTP1-1 and GSTM2-2 with IC50 of 25 uM, 0.8 uM and <0.01 uM, is cytotoxic toward P-glycoprotein-overexpressing tumor cell lines.
NBDHEX not only is cytotoxic toward the parental small cell lung cancer H69 cell line (LC(50) of 2.3 +/- 0.6 micromol/L) but also overcomes the multidrug resistance of its variant, H69AR, which overexpresses the ATP-binding cassette transporter multidrug resistance-associated protein 1 (MRP1; LC(50) of 4.5 +/- 0.9 micromol/L).
NBDHEX overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer.
NBDHEX overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells.

物理化学性质&存储条件

分子量	297.33
分子式	C12H15N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol

参考文献

1. Ricci G, et al. J Biol Chem. 2005 Jul 15;280(28):26397-405.

2. Turella P, et al. J Biol Chem. 2006 Aug 18;281(33):23725-32.

3. Filomeni G, et al. Mol Cancer Ther. 2008 Feb;7(2):371-9.

NBDHEX

生物&药学活性

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