1,2,3,6-Tetragalloylglucose (TeGG) | UGT1A1 inhibitor

Chemical Structure : TeGG

CAS No.: 79886-50-3

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TeGG (1,2,3,6-Tetragalloylglucose)

货号: PC-26075Not For Human Use, Lab Use Only.

1,2,3,6-Tetragalloylglucose (TeGG) is a substrate competitive inhibitor of UDP-glucuronyltransferase UGT1A1, inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 uM and 4.31 uM, respectively.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

1,2,3,6-Tetragalloylglucose (TeGG) is a substrate competitive inhibitor of UDP-glucuronyltransferase UGT1A1, inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 uM and 4.31 uM, respectively.
1,2,3,6-Tetragalloylglucose (TeGG) directly binds to UGT1A1 with Ki of 3.55 uM.
1,2,3,6-Tetragalloylglucose (TeGG) induces tumor cell apoptosis, inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells.
1,2,3,6-Tetragalloylglucose (TeGG) also inhibits HIV integrase and reverse transcriptase, and inhibits HCV protease.
1,2,3,6-Tetragalloylglucose (TeGG) also inhibits heterogeneous nuclear ribonucleoprotein A2B1 (A2B1), inhibits hnRNPA2B1/TRAIL Axis to attenuate apoptosis and barrier dysfunction in intestinal epithelial cells.

物理化学性质&存储条件

分子量	788.58
分子式	C34H28O22
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4S,5R,6R)-5-Hydroxy-6-(((3,4,5-trihydroxybenzoyl)oxy)methyl)tetrahydro-2H-pyran-2,3,4-triyl tris(3,4,5-trihydroxybenzoate)

参考文献

1. Park JB, et al. Food Chem Toxicol. 2018 Oct;120:651-661.

2. Wang C, et al. Cell Signal. 2026 Feb 4;142:112411.

3. Zhang J, et al. Pharm Res. 2009 Sep;26(9):2066-80.

TeGG (1,2,3,6-Tetragalloylglucose)

生物&药学活性

物理化学性质&存储条件

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TeGG (1,2,3,6-Tetragalloylglucose)

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物理化学性质&存储条件

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