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首页-小分子抑制剂&激动剂-Others-Other Targets-XM462
XM462

Chemical Structure : XM462

CAS No.: 1045857-53-1

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XM462 (XM-462)

货号: PC-26799Not For Human Use, Lab Use Only.

XM462 is a small molecule inhibitor of dihydroceramide desaturase (Des1) with IC50 of 8.2 uM and Ki of 2 uM, inhibits sphingolipid synthesis, triggers autophagy and reduces amyloid secretion by neurons.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

XM462 is a small molecule inhibitor of dihydroceramide desaturase (Des1) with IC50 of 8.2 uM and Ki of 2 uM, inhibits sphingolipid synthesis, triggers autophagy and reduces amyloid secretion by neurons.

物理化学性质&存储条件

分子量 445.75
分子式 C25H51NO3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((2S,3S)-1,3-dihydroxy-4-(tridecylthio)butan-2-yl)octanamide

参考文献

1. Munoz-Olaya JM, et al. ChemMedChem. 2008 Jun;3(6):946-53.

2. Ordóñez-Gutiérrez L, et al. Pharm Res. 2018 Feb 6;35(3):49.

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