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首页-小分子抑制剂&激动剂-Others-Other Targets-GAA-4OH
GAA-4OH

Chemical Structure : GAA-4OH

CAS No.:

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GAA-4OH

货号: PC-26765Not For Human Use, Lab Use Only.

GAA-4OH is a potent and irreversible inhibitor of dihydroceramide desaturase-1 (DEGS1), covalently blocks the enzyme catalytic cavity, reduces ceramide-to-dihydroceramide ratios and improves steatosis, inflammation, and fibrosis in mouse model of MASLD.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GAA-4OH is a potent and irreversible inhibitor of dihydroceramide desaturase-1 (DEGS1), covalently blocks the enzyme catalytic cavity, reduces ceramide-to-dihydroceramide ratios and improves steatosis, inflammation, and fibrosis in mouse model of MASLD.

物理化学性质&存储条件

分子量 517.71
分子式 C33H43NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2E,6E,10E)-13-((R)-6-hydroxy-2,8-dimethylchroman-2-yl)-N-(4-hydroxyphenyl)-2,6,10-trimethyltrideca-2,6,10-trienamide

参考文献

1. Cevallos K, et al. J Med Chem. 2026 May 4. doi: 10.1021/acs.jmedchem.5c03686.

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