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首页-小分子抑制剂&激动剂-Others-Other Targets-Kukoamine A
Kukoamine A

Chemical Structure : Kukoamine A

CAS No.: 75288-96-9

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Kukoamine A (KuA)

货号: PC-26771Not For Human Use, Lab Use Only.

Kukoamine A (KuA) is a potent and selective inhibitor of Crithidia fasciculata trypanothione reductase (TR) with Ki of 1.8 uM, with no significant inhibition on human glutathione reductase, possesses antioxidant, anti-inflammatory activities.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Kukoamine A (KuA) is a potent and selective inhibitor of Crithidia fasciculata trypanothione reductase (TR) with Ki of 1.8 uM, with no significant inhibition on human glutathione reductase, possesses antioxidant, anti-inflammatory activities.
Kukoamine A inhibits human glioblastoma cell growth and migration in vitro and in vivo through apoptosis induction and epithelial-mesenchymal transition attenuation by downregulating expressions of 5-LOX and C/EBPβ.
Kukoamine A disrupts AARS2-AP-2γ interaction and, demonstrates improved liver targeting, potent antitumour activity and synergy with PD-1 blockade in hepatocellular carcinoma (HCC).

物理化学性质&存储条件

分子量
分子式 C28H42N4O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzenepropanamide, N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-

参考文献

1. Ponasik JA, et al. Biochem J. 1995 Oct 15;311 ( Pt 2)(Pt 2):371-5.

2. Chitkul B, et al. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2367-9.

3. Wang Q, et al. Sci Rep. 2016 Nov 8;6:36543.

4. Li Q, et al. Gut. 2026 May 11:gutjnl-2025-337330.

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