CCT365623 | LOX inhibitor | Probechem Biochemicals

Chemical Structure : CCT365623

CAS No.: 2126134-01-6

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CCT365623 (CCT-365623)

货号: PC-61189Not For Human Use, Lab Use Only.

CCT365623 (CCT-365623) is a potent, orally active small molecule inhibitor of lysyl oxidase (LOX) with IC50 of 0.89 uM.

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5 mg	￥2880	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
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100 mg		Get quote

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生物&药学活性

CCT365623 (CCT-365623) is a potent, orally active small molecule inhibitor of lysyl oxidase (LOX) with IC50 of 0.89 uM.
CCT365623 is ∼16-fold more potent than BAPN (IC50=14.7 uM).
CCT365623 displays excellent selectivity (over 350-fold) for LOX over amine oxidase A and B (MAO-A, MAO-B) and is over 1,000-fold more selective for LOX over serum diamine oxidase.
CCT365623 inhibits LOX at ∼5 μM in MDCK cysts, whereas BAPN inhibits LOX at ∼250 μM.
CCT365623 suppresses EGFR and AKT phosphorylation driven by EGF, also inhibits HTRA1 multimer formation.
CCT365623 blocks tumour growth and metastasis in a mouse model of spontaneous breast cancer that metastasizes to the lungs.

物理化学性质&存储条件

分子量	407.517
分子式	C18H17NO4S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-((5-(methylsulfonyl)-[1,1'-biphenyl]-3-yl)sulfonyl)thiophen-2-yl)methanamine

参考文献

1. Tang H, et al. Nat Commun. 2017 Apr 18;8:14909.

CCT365623 (CCT-365623)

生物&药学活性

物理化学性质&存储条件

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CCT365623 (CCT-365623)

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