PHB1 inhibitor TD6

Chemical Structure : PHB1 inhibitor TD6

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货号: PC-27301Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PHB1 inhibitor TD6 is a highly potent and selective small-molecule inhibitor of Prohibitin 1 (PHB1), exerts potent anti-tumor activities against CRC, effectively suppresses tumor growth and dissemination by disrupting mitochondrial energy metabolism.
TD6 (5-10 uM) potently suppresses CRC cell migratory capacity.
TD6 impairs mitochondrial complex I (MCI) stability by disrupting the PHB-NDUFS1 interaction, markedly reduces the protein level of NDUFS1 preferentially via lysosomal degradation rather than proteasomal pathways.
TD6 (40 mg/kg) induces tumor suppression in CT26-drived CRPM mice.
TD6 increased phosphorylation of AMPKα at Thr172 and ACC at Ser80 in T84 and HCT116 cells, suggesting activation of AMPK signaling.
TD6 inhibits mitochondrial OXPHOS in CRC cells, impairs MCI activity and ATP production.

物理化学性质&存储条件

分子量	545.70
分子式	C30H35N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((N-(2-(dimethylamino)ethyl)-4-methylphenyl)sulfonamido)-N-(1-(3,4-dimethylphenyl)-4-phenyl-1H-imidazol-2-yl)acetamide

参考文献

1. Wang K, et al. Redox Biol. 2026 Jul 8;95:104291.