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首页-小分子抑制剂&激动剂-Others-Other Targets-G2A antagonist 65
G2A antagonist 65

Chemical Structure : G2A antagonist 65

CAS No.:

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G2A antagonist 65

货号: PC-27319Not For Human Use, Lab Use Only.

G2A antagonist 65 is a potent, selective G protein coupled receptor 132 (GPR132 or G2A) antagonist with IC50 of 0.69 uM, prevents the 9-HODE-mediated sensitization of capsaicin-induced TRPV1 responses in primary sensory neurons.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

G2A antagonist 65 is a potent, selective G protein coupled receptor 132 (GPR132 or G2A) antagonist with IC50 of 0.69 uM, prevents the 9-HODE-mediated sensitization of capsaicin-induced TRPV1 responses in primary sensory neurons.

物理化学性质&存储条件

分子量 419.26
分子式 C19H16Cl2N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3,4-Dichlorophenyl)-2-(2-(3,5-dimethylisoxazol-4-yl)acetamido)isonicotinamide

参考文献

1. Victor Hernandez-Olmos, et al. J Med Chem. 2026 Jun 25;69(12):14309-14332.

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