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Elamipretide acetate

Chemical Structure : Elamipretide acetate

CAS No.: 1334953-95-5

Elamipretide acetate (SS-31, MTP 131 acetate, Bendavia)

货号: PC-27242Not For Human Use, Lab Use Only.

Elamipretide acetate (SS-31, MTP-131, Bendavia) is a novel cell-permeable antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that targets inner mitochondrial membrane and prevents oxidative damage of neuronal cells and other cell types.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Elamipretide acetate (SS-31, MTP-131, Bendavia) is a novel cell-permeable antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that targets inner mitochondrial membrane and prevents oxidative damage of neuronal cells and other cell types.
Elamipretide prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function.

物理化学性质&存储条件

分子量 699.85
分子式 C34H53N9O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-6-amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((R)-2-amino-5-guanidinopentanamido)-3-(4-hydroxy-2,6-dimethylphenyl)propanamido)hexanamide acetate

参考文献

1. Thomas DA, et al. J Am Soc Nephrol. 2007 Jan;18(1):213-22.

2. Zhao K, et al. Biochem Pharmacol. 2005 Dec 5;70(12):1796-806.

3. Mizuguchi Y, et al. Am J Physiol Renal Physiol. 2008 Nov;295(5):F1545-53.

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