RUN-89 | NRF1 activator | Probechem Biochemicals

Chemical Structure : RUN-89

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RUN-89 (RUN89)

货号: PC-27289Not For Human Use, Lab Use Only.

RUN-89 is a potent, specific activator of transcription factor nuclear factor erythroid 2-related factor 1 (encoded by NFE2L1, NRF1) with EC50 of 3.1 uM.

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生物&药学活性

RUN-89 is a potent, specific activator of transcription factor nuclear factor erythroid 2-related factor 1 (encoded by NFE2L1, NRF1) with EC50 of 3.1 uM.
RUN-89 activates the NFE2L1-specific luciferase reporter independently of the KEAP1-NFE2L2 pathway.
RUN-89 significantly elevates total LC3 protein levels in HEK293 cells, modulates proteasome activity, autophagy, and cell survival.
RUN-89 inhibits the formation of huntingtin Q74 aggregates in U2OS cells expressing EGFP-HttQ74.
RUN-89 activates the SKN-1A/NFE2L1 pathway in C. elegans, prevents protein aggregation, and enhances stress resilience in vivo.

物理化学性质&存储条件

分子量	505.61
分子式	C30H35NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,5-bis((E)-3,4-dimethoxybenzylidene)-4-oxocyclohexyl)cyclopentanecarboxamide

参考文献

1. Zuzana Smahelova, et al. RSC Med Chem. 2025 Oct 22;16(12):6397-6411.

RUN-89 (RUN89)

生物&药学活性

物理化学性质&存储条件

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RUN-89 (RUN89)

生物&药学活性

物理化学性质&存储条件

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