Vosoritide | C-type natriuretic peptide analog, NPR2 agonist

Chemical Structure : Vosoritide

CAS No.: 1480724-61-5

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Vosoritide (BMN-111, BMN111, BMN 111)

货号: PC-27287Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3880	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

Vosoritide (BMN-111) is a biologic analogue of C-type natriuretic peptide (CNP) and a potent stimulator of endochondral ossification, acts to restore chondrogenesis through its binding to natriuretic peptide receptor B (NPR-B, NPR2), resulting in the inhibition of downstream signalling pathways of the overactive FGFR3 gene.
Vosoritide (BMN-111) antagonizes FGFR3 downstream signaling by inhibiting the pathway of mitogen-activated protein kinase (MAPK).
Vosoritide (BMN-111) has a half-life 10 times that of CNP.
Vosoritide (BMN-111) is effective in significantly increasing the annualized growth velocity in children with achondroplasia before the fusion of the epiphyses.

物理化学性质&存储条件

分子量	4102.73
分子式	C176H290N56O51S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pro-Gly-Gln-Glu-His-Pro-Asn-Ala-Arg-Lys-Tyr-Lys-Gly-Ala-Asn-Lys-Lys-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys (Disulfide bridge:Cys23-Cys39)

参考文献

1. Savarirayan R, et al. N Engl J Med. 2019 Jul 4;381(1):25-35.

Vosoritide (BMN-111, BMN111, BMN 111)

生物&药学活性

物理化学性质&存储条件

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Vosoritide (BMN-111, BMN111, BMN 111)

生物&药学活性

物理化学性质&存储条件

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