OXGR1 agonist A-1

Chemical Structure : OXGR1 agonist A-1

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货号: PC-26371Not For Human Use, Lab Use Only.

OXGR1 agonist A-1 is a potent and selective OXGR1 (Oxoglutarate Receptor 1, GPR99) agonist, activates Gq signaling of OXGR1 with EC50 of 626.5 nM.

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生物&药学活性

OXGR1 agonist A-1 is a potent and selective OXGR1 (Oxoglutarate Receptor 1, GPR99) agonist, activates Gq signaling of OXGR1 with EC50 of 626.5 nM.
A-1 activates OXGR1 with a potency approximately 60 times stronger compared with α-KG.
A-1 shows no detectable activity for GPR91.
OXGR1-F113L mutant reduced the potency of A-1 by more than 10,000-fold.
A-1 promoted phosphorylation of MYL9 and MLCK expression in VSMCs comparable to α-KG.
A-1 (80 uM) obviously improved rosacea-related phenotypes when applied topically to the back skins of mice.
A-1 mitigates erythema and inflammation with efficacy comparable to first-line therapy while offering enhanced safety in rosacea-like models.

物理化学性质&存储条件

分子量	191.20
分子式	C6H9NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (1,1-dioxido-2,3-dihydrothiophen-3-yl)carbamate

参考文献

1. Xiao W, et al. Cell. 2026 Mar 5:S0092-8674(26)00164-9. doi: 10.1016/j.cell.2026.01.036.

OXGR1 agonist A-1

生物&药学活性

物理化学性质&存储条件

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OXGR1 agonist A-1

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物理化学性质&存储条件

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