(3S) ALG-05 | TILs inhibitor | Probechem Biochemicals

Chemical Structure : (3S) ALG-05

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(3S) ALG-05 ((3S)ALG-05)

货号: PC-21142Not For Human Use, Lab Use Only.

(3S) ALG-05 is a potent pan-inhibitor of gut microbia tryptophan-indole-lyases (TILs, E.C. 4.1.99.1), exhibits inhibitory activity across TILs with Ki of 7-11 uM.

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生物&药学活性

(3S) ALG-05 is a potent pan-inhibitor of gut microbia tryptophan-indole-lyases (TILs, E.C. 4.1.99.1), exhibits inhibitory activity across TILs with Ki of 7-11 uM.
(3S) ALG-05 is non-lethal and capable of inhibiting Ec TIL intracellularly.
(3S) ALG-05 displays target engagement with minimal toxicity in cells.
(3S) ALG-05 (140 mg/kg, oral gavage) significantly reduces levels of cecal indole and serum indoxyl sulfate (IS) in C57BL/6 mice.
TILs are pyridoxal 5′-phosphate (PLP)-dependent enzymes that catalyze α,β-elimination and β-replacement reactions to generate pyruvate, ammonia, and indole.

物理化学性质&存储条件

分子量	254.67
分子式	C11H11ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-3-((S)-3-chloro-2-oxoindolin-3-yl)propanoic acid

参考文献

1. Amanda L Graboski, et al. Cell Chem Biol. 2023 Aug 12;S2451-9456(23)00244-1.

(3S) ALG-05 ((3S)ALG-05)

生物&药学活性

物理化学性质&存储条件

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(3S) ALG-05 ((3S)ALG-05)

生物&药学活性

物理化学性质&存储条件

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