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VJDT

Chemical Structure : VJDT

CAS No.: 2765319-65-9

VJDT (TREM1 inhibitor VJDT)

货号: PC-21113Not For Human Use, Lab Use Only.

VJDT (TREM1 inhibitor) is a novel small molecule inhibitor of triggering receptor expressed on myeloid cell 1 (TREM1), effectively blocks TREM1 signaling.

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5 mg ¥1980 In stock
10 mg ¥2980 In stock
25 mg ¥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VJDT (TREM1 inhibitor) is a novel small molecule inhibitor of triggering receptor expressed on myeloid cell 1 (TREM1), effectively blocks TREM1 signaling.
VJDT significantly attenuates cell proliferation and migration in HepG2 and B16F10 cells.
VJDT (20 mg/kg) significantly suppresses the growth in human skin cutaneous melanoma PDX model.
VJDT inhibits many cellular proliferation and migration signaling pathways, such as the PI3K-Akt and the PI3K-Akt-mTOR focal adhesion pathways.
VJDT strongly downregulated genes associated with cell proliferation (STAT3, NFKB1, and JUN) and those associated with immune cell infiltration (CCL20, CXCL8, CXCL10, and IL1B).
VJDT downregulates key oncogenic signaling pathways involved in cell proliferation, migration, and survival in melanoma patient-derived xenograft tumors.

物理化学性质&存储条件

分子量 383.41
分子式 C23H17N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

9-benzyl-1,3,8-trioxo-2-phenyl-2,3,3a,4,7,7a-hexahydro-1H-4,7-(epiminomethano)isoindole-5-carbonitrile

参考文献

1. Ajith A, et al. J Clin Invest. 2023 Aug 31:e167951.

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