DSHN-OMe | NR0B2 agonist | Probechem Biochemicals

Chemical Structure : DSHN-OMe

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DSHN-OMe (DSHN methyl ester)

货号: PC-21099Not For Human Use, Lab Use Only.

DSHN-OMe (DSHN methyl ester) is a small molecule modulator of NR0B2, effectively reduces induction of LXR target gene ABCA1 by GW3965 (1 uM) in BMDMs with IC50 of 3.8 uM, reduces regulatory T cell expansion and impede breast cancer progression.

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生物&药学活性

DSHN-OMe (DSHN methyl ester) is a small molecule modulator of NR0B2, effectively reduces induction of LXR target gene ABCA1 by GW3965 (1 uM) in BMDMs with IC50 of 3.8 uM, reduces regulatory T cell expansion and impede breast cancer progression.
DSHN-OMe significantly reduced the outgrowth of established 4T1 metastatic lesions as a single agent.
DSHN-OMe also significantly reduced metastatic burden in mice grafted with EMT6 cells, an alternative murine mammary cancer model.
DSHN-OMe decreased FOXP3 expression in EMT6 metastatic lungs models.
NR0B2 is a protein involved in cholesterol homeostasis, functions within myeloid immune cells to modulate the NLRP3 inflammasome and reduce the expansion of immune-suppressive regulatory T cells (Treg).

物理化学性质&存储条件

分子量	337.39
分子式	C16H19NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 5-(N,N-diethylsulfamoyl)-3-hydroxy-2-naphthoate

参考文献

1. Hashni Epa Vidana Gamage, et al. bioRxiv. 2023 Aug 14;2023.08.14.553229.

DSHN-OMe (DSHN methyl ester)

生物&药学活性

物理化学性质&存储条件

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DSHN-OMe (DSHN methyl ester)

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物理化学性质&存储条件

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