C10M | CRP inhibitor | Probechem Biochemicals

Chemical Structure : C10M

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C10M (CRP inhibitor C10M)

货号: PC-21057Not For Human Use, Lab Use Only.

C10M is a small molecule inhibitor of C-reactive protein (CRP), inhibits the binding of pCRP to the physiological ligand phosphocholine (PC) with IC50 of 1.5 mM in ELISA assays.

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生物&药学活性

C10M is a small molecule inhibitor of C-reactive protein (CRP), inhibits the binding of pCRP to the physiological ligand phosphocholine (PC) with IC50 of 1.5 mM in ELISA assays.
C10M inhibits CRP-induced monocyte adhesion, expression of pro-inflammatory cytokines, and formation of platelet-leukocyte aggregates was evaluated in-vitro.
C10M inhibits pCRP binding to activated platelets and microvesicles and reduces pCRP*/mCRP induced ICAM-1 and VCAM-1 expression on human endothelial cells and activation of leukocytes.
C10M inhibits CRP-induced aggravation of renal ischemia/reperfusion injury, inhibits pCRP*/mCRP-induced aggravation of allograft rejection in a hindlimb transplantation model.

物理化学性质&存储条件

分子量	251.31
分子式	C11H26NO3P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-(dibutylamino)propyl)phosphonic acid

C10M (CRP inhibitor C10M)

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物理化学性质&存储条件

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C10M (CRP inhibitor C10M)

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