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首页-小分子抑制剂&激动剂-Others-Other Targets-ZINC 39395747
ZINC 39395747

Chemical Structure : ZINC 39395747

CAS No.: 1801163-44-9

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ZINC 39395747 (ZINC39395747, ZINC-39395747)

货号: PC-60880Not For Human Use, Lab Use Only.

ZINC 39395747 is a novel potent derivative of propylthiouracil that functions as a cell-active inhibitor of cytochrome b5 reductase 3 (CYB5R3) with IC50 of 9.14 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ZINC 39395747 is a novel potent derivative of propylthiouracil that functions as a cell-active inhibitor of cytochrome b5 reductase 3 (CYB5R3) with IC50 of 9.14 uM.
    ZINC 39395747 significantly increases NO bioavailability in renal vascular cells, augments renal blood flow, and decreases systemic blood pressure in response to vasoconstrictors in spontaneously hypertensive rats.

    物理化学性质&存储条件

    分子量 293.359
    分子式 C12H11N3O2S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-6-(((2,3-dihydrobenzo[d]oxazol-2-yl)thio)methyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

    参考文献

    1. Rahaman MM, et al. J Biol Chem. 2015 Jul 3;290(27):16861-72.

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