S1P Lyase inhibitor 31 |CAS:1538574-95-6 Probechem Biochemicals

Chemical Structure : S1P Lyase inhibitor 31

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S1P Lyase inhibitor 31 (S1PL inhibitor 31)

货号: PC-60693Not For Human Use, Lab Use Only.

S1P Lyase inhibitor 31 is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM.

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25 mg		Get quote
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250 mg		Get quote
1 g		Get quote

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生物&药学活性

S1P Lyase inhibitor 31 is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM.
S1P Lyase inhibitor 31 displays acceptable selectivity in a panel of 74 receptors and enzymes at 10 uM.
S1P Lyase inhibitor 31 induces profound reduction of peripheral T cell numbers after oral dosage and confers pronounced protection in a rat model of multiple sclerosis.

物理化学性质&存储条件

分子量	454.962
分子式	C26H23ClN6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[(2R)-4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile

参考文献

1. Harris CM, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):151-8.

2. Weiler S, et al. J Med Chem. 2014 Jun 26;57(12):5074-84.

S1P Lyase inhibitor 31 (S1PL inhibitor 31)

生物&药学活性

物理化学性质&存储条件

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S1P Lyase inhibitor 31 (S1PL inhibitor 31)

生物&药学活性

物理化学性质&存储条件

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