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Brequinar

Chemical Structure : Brequinar

CAS No.: 96187-53-0

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Brequinar (DuP785, NSC 368390)

货号: PC-62689Not For Human Use, Lab Use Only.

Brequinar (DuP785, NSC 368390) is a potent and selective inhibitor of DHODH with IC50 of 20 nM, triggers differentiation in the ER-HoxA9, U937, and THP1 cells with an ED50 of 1 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Brequinar (DuP785, NSC 368390) is a potent and selective inhibitor of DHODH with IC50 of 20 nM, triggers differentiation in the ER-HoxA9, U937, and THP1 cells with an ED50 of 1 uM.
Brequinar arrests tumor growth in HL60 and MOLM13 subcutaneous xenograft models of AML in NOD SCID mice.

物理化学性质&存储条件

分子量 375.37
分子式 C23H15F2NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid

参考文献

1. Sykes DB, et al. Cell. 2016 Sep 22;167(1):171-186.e15.

2. Dexter DL, et al. Cancer Res. 1985 Nov;45(11 Pt 1):5563-8.

3. Chen SF, et al. Cancer Res. 1986 Oct;46(10):5014-9.

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