Retro-2 (Retro 2) | Ricin inhibitor, Retrograde transport inhibitor

Chemical Structure : Retro-2

CAS No.: 1201652-50-7

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Retro-2 (Retro 2, Retro2)

货号: PC-62658Not For Human Use, Lab Use Only.

Retro 2 (Retro-2) is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface.

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10 mg	￥1980	In stock
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生物&药学活性

Retro-2 (Retro 2) is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface.
Retro-2 has no effect on endogenous retrograde cargo proteins.
Retro-2 is an ebolavirus (EBOV) infection inhibitor with EC50 of 12.2 μ\uM in HeLa cells.
Retro-2 protects mice against ricin challenge.

物理化学性质&存储条件

分子量	320.41
分子式	C19H16N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(((5-methylthiophen-2-yl)methylene)amino)-N-phenylbenzamide

参考文献

1. Stechmann B, et al. Cell. 2010 Apr 16;141(2):231-42.

Retro-2 (Retro 2, Retro2)

生物&药学活性

物理化学性质&存储条件

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Retro-2 (Retro 2, Retro2)

生物&药学活性

物理化学性质&存储条件

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