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首页-小分子抑制剂&激动剂-Others-Other Targets-Retro 1
Retro 1

Chemical Structure : Retro 1

CAS No.: 313683-81-7

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Retro 1 (Retro-1)

货号: PC-62657Not For Human Use, Lab Use Only.

Retro 1 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Retro 1 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface.
    Retro 1 has no effect on endogenous retrograde cargo proteins; protects mice against ricin challenge.

    物理化学性质&存储条件

    分子量 373.25
    分子式 C18H17BrN2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one

    参考文献

    1. Stechmann B, et al. Cell. 2010 Apr 16;141(2):231-42.

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