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首页-小分子抑制剂&激动剂-Others-Other Targets-SJ572946
SJ572946

Chemical Structure : SJ572946

CAS No.: 78584-09-5

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SJ572946 (SJ 572946)

货号: PC-20313Not For Human Use, Lab Use Only.

SJ572946 is a small molecule BAK activator, binds to the activation groove of BAK and selectively triggers BAK activation over that of BAX in liposome and mitochondrial permeabilization assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SJ572946 is a small molecule BAK activator, binds to the activation groove of BAK and selectively triggers BAK activation over that of BAX in liposome and mitochondrial permeabilization assays.
    In combination with apoptotic inducers and BH3 mimetics, SJ572946 kills experimental cancer cell lines.
    SJ572946 also cooperates with the endogenous BAK activator BID in activating a misfolded BAK mutant substantially impaired in activation.

    物理化学性质&存储条件

    分子量 198.67
    分子式 C8H7ClN2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-chloro-4-methylbenzo[d]thiazol-2-amine

    参考文献

    1. Giridhar Sekar, et al. iScience. 2022 Sep 6;25(10):105064.

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