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首页-小分子抑制剂&激动剂-Others-Other Targets-HTL0041178
HTL0041178

Chemical Structure : HTL0041178

CAS No.: 2642079-89-6

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HTL0041178 (HTL 0041178)

货号: PC-20325Not For Human Use, Lab Use Only.

HTL0041178 is a potent GPR52 agonist with EC50 of 27.5 nM (human or rat GPR52).

规格 价格 库存 数量
5 mg ￥2280 In stock
10 mg ￥3780 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HTL0041178 is a potent GPR52 agonist with EC50 of 27.5 nM (human or rat GPR52).
HTL0041178 exhibits a promising pharmacokinetic (PK) profile, and oral activity in rodent preclinical models.
HTL0041178 (10 mg/kg, p.o.) caused a dose-related reduction in d-amphetamine-stimulated hyperlocomotion in rats.

物理化学性质&存储条件

分子量 390.34
分子式 C19H14F4N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2-(3-fluoro-5-(trifluoromethyl)benzyl)pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrazolo[4,3-c]pyridin-4-one

参考文献

1. Patent WO2021090030.

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