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首页-小分子抑制剂&激动剂-Others-Other Targets-Secdin
Secdin

Chemical Structure : Secdin

CAS No.: 701231-07-4

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Secdin

货号: PC-20318Not For Human Use, Lab Use Only.

Secdin is a small-molecule inhibitor of Arabidopsis thaliana ADP-ribosylation factor (ARF)-guanine nucleotide exchange factors (GEFs), impaires both hypocotyl and root growth in young Arabidopsis seedlings with IC50 of 4 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Secdin is a small-molecule inhibitor of Arabidopsis thaliana ADP-ribosylation factor (ARF)-guanine nucleotide exchange factors (GEFs), impaires both hypocotyl and root growth in young Arabidopsis seedlings with IC50 of 4 uM.
    Secdin (50 µM) did not affect seed germination.
    Secdin application causes aberrant retention of plasma membrane (PM) proteins in late endosomal compartments, enhances vacuolar degradation, impaires protein recycling, and delays secretion and endocytosis.
    Combined treatments with Secdin and the known ARF-GEF inhibitor Brefeldin A (BFA) prevents the BFA-induced PM stabilization of the ARF-GEF GNOM, impaires its translocation from the Golgi to the trans-Golgi network/early endosomes, and lead to the formation of hybrid endomembrane compartments reminiscent of those in ARF-GEF-deficient mutants.
    Secdin impaires the intracellular transport of PM-localized proteins without directly affecting general aspects of the plant cell homeostasis.

    物理化学性质&存储条件

    分子量 454.53
    分子式 C27H26N4O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-methyl-4-(4-(2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy)phenyl)phthalazin-1(2H)-one

    参考文献

    1. Kiril Mishev, et al. Plant Cell. 2018 Oct;30(10):2573-2593.

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