Emixustat (ACU-4429) hydrochloride | RPE65 inhibitor | Probechem Biochemicals

Chemical Structure : Emixustat hydrochloride

CAS No.: 1141934-97-5

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Emixustat hydrochloride (ACU-4429 hydrochloride)

货号: PC-45685Not For Human Use, Lab Use Only.

Emixustat (ACU-4429) hydrochloride is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.

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10 mg	￥1980	In stock
25 mg	￥3480	In stock
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生物&药学活性

Emixustat (ACU-4429) hydrochloride is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.
Emixustat (ACU-4429) reduces the production of visual chromophore (11-cis retinal) in wild-type mice following a single oral dose (ED50 = 0.18 mg/kg).

物理化学性质&存储条件

分子量	299.8362
分子式	C16H26ClNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 44 mg/mL
Chemical Name/SMILES	Benzenemethanol, α-(2-aminoethyl)-3-(cyclohexylmethoxy)-, hydrochloride (1:1), (αR)-

参考文献

1. Kiser PD, et al. Nat Chem Biol. 2015 Jun;11(6):409-15.

2. Bavik C, et al. PLoS One. 2015 May 13;10(5):e0124940.

3. Zhang J, et al. J Clin Invest. 2015 Jul 1;125(7):2781-94.

Emixustat hydrochloride (ACU-4429 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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Emixustat hydrochloride (ACU-4429 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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