C1632 | Lin28 inhibitor | Probechem Biochemicals

Chemical Structure : C1632

CAS No.: 108825-65-6

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C1632 (Lin28-IN-1632)

货号: PC-70001Not For Human Use, Lab Use Only.

C1632 (Lin28-IN-1632) is a small molecule inhibitor of RNA binding protein Lin28 that blocks the Lin28/let-7 interaction, rescues let-7 processing and function in Lin28-expressing cancer cells.

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10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

C1632 (Lin28-IN-1632) is a small molecule inhibitor of RNA binding protein Lin28 that blocks the Lin28/let-7 interaction, rescues let-7 processing and function in Lin28-expressing cancer cells.
C1632 inhibits Lin28A from pre-let-7a-2 binding at IC50 of 8 uM; induces differentiation of mouse embryonic stem cells, and reduces tumor-sphere formation by 22Rv1 and Huh7 cells.
C1632 inhibits proliferation and stem-like properties in human cancer cells (22Rv1, PC3, DU145, and Huh7) with GI50 of 20-80 uM.

物理化学性质&存储条件

分子量	281.3
分子式	C15H15N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-methyl-N-[3-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide

参考文献

1. Roos M, et al. ACS Chem Biol. 2016 Oct 21;11(10):2773-2781.

C1632 (Lin28-IN-1632)

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物理化学性质&存储条件

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C1632 (Lin28-IN-1632)

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物理化学性质&存储条件

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