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trans-AUCB

Chemical Structure : trans-AUCB

CAS No.: 885012-33-9

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trans-AUCB (t-AUCB)

货号: PC-60090Not For Human Use, Lab Use Only.

trans-AUCB is a potent, specific and orally bioavailable soluble epoxide hydrolase (sEH) inhibitor with IC50 of 1.3 nM.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

trans-AUCB is a potent, specific and orally bioavailable soluble epoxide hydrolase (sEH) inhibitor with IC50 of 1.3 nM.
trans-AUCB shows potential in vivo to treat hypotension in lipopolysaccharide challenged murine models.
trans-AUCB prevents the pericyte loss and vascular permeability in animal model of diabetic retinopathy.

物理化学性质&存储条件

分子量 412.5
分子式 C24H32N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid

参考文献

1. Hwang SH, et al. J Med Chem. 2007 Aug 9;50(16):3825-40.

2. Hwang SH, et al. J Med Chem. 2011 Apr 28;54(8):3037-50.

3. Hu J, et al. Nature. 2017 Dec 14;552(7684):248-252.

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