GIBH-130 |CAS:1252608-59-5 Probechem Biochemicals

Chemical Structure : GIBH-130

CAS No.: 1252608-59-5

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GIBH-130 (GIBH 130, GIBH130)

货号: PC-60175Not For Human Use, Lab Use Only.

GIBH-130 is a small molecule inhibitor of neuroinflammation, suppresses the proinflammatory cytokine production in LPS-stimulated N9 microglial cells (IC50=3.4 nM).

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

GIBH-130 is a small molecule inhibitor of neuroinflammation, suppresses the proinflammatory cytokine production in LPS-stimulated N9 microglial cells (IC50=3.4 nM).
GIBH-130 modulates the release of detrimental proinflammatory cytokines.
GIBH-130 exhibits in vivo efficacy of cognitive impairment in both β amyloid-induced and APP/PS1 double transgenic Alzheimer's murine models.

物理化学性质&存储条件

分子量	360.421
分子式	C20H20N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-methyl-6-phenylpyridazin-3-yl)(4-(pyrimidin-2-yl)piperazin-1-yl)methanone

参考文献

1. Zhou W, et al. ACS Chem Neurosci. 2016 Nov 16;7(11):1499-1507.

GIBH-130 (GIBH 130, GIBH130)

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GIBH-130 (GIBH 130, GIBH130)

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物理化学性质&存储条件

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