IVMT-Rx-4

Chemical Structure : IVMT-Rx-4

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货号: PC-26386Not For Human Use, Lab Use Only.

IVMT-Rx-4 is a small molecule inhibitor of MDA-9/Syntenin, specifically interrupt MDA-9/Syntenin signaling, leading to an inhibition in progression of PC cells to bone metastasis.

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生物&药学活性

IVMT-Rx-4 is a small molecule inhibitor of MDA-9/Syntenin, specifically interrupt MDA-9/Syntenin signaling, leading to an inhibition in progression of PC cells to bone metastasis.
IVMT-Rx-4 is a synthetic intermediate of MDA-9/Syntenin antagonist PDZ1i, exhibits greater efficacy compared to PDZ1i.
IVMT-Rx-4 inhibits NF-κB activation and PDGF-AA expression in different PC cell lines.
IVMT-Rx-4 inhibits PDGF-AA-induced CXCL5 expression in bone marrow derived mesenchymal stromal cells (BM-MSCs).
IVMT-Rx-4 (30 mg/kg body weight) inhibits experimental bone metastasis and enhances animal survival, the combination of IVMT-Rx-4 and docetaxel enhances survival in experimental bone metastasis models.

物理化学性质&存储条件

分子量	336.40
分子式	C19H20N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-amino-2,5-dimethylphenyl)-3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanamide

参考文献

1. Maji S, et al. Pharmacol Res. 2026 Mar 20:108164.

2. Kegelman TP, et al. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):370-375.

IVMT-Rx-4

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IVMT-Rx-4

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