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首页-小分子抑制剂&激动剂-Others-Other Targets-BI-0115
BI-0115

Chemical Structure : BI-0115

CAS No.: 4929-23-1

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BI-0115 (BI0115, BI 0115)

货号: PC-26812Not For Human Use, Lab Use Only.

BI-0115 is a selective small molecule inhibitor of lectin-like oxidized LDL receptor-1 (LOX-1) with IC50 of 5.4 uM, blocks cellular uptake of oxidized low-density lipoproteins (oxLDL).

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10 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BI-0115 is a selective small molecule inhibitor of lectin-like oxidized LDL receptor-1 (LOX-1) with IC50 of 5.4 uM, blocks cellular uptake of oxidized low-density lipoproteins (oxLDL).
BI-0115 triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain.

物理化学性质&存储条件

分子量 287.75
分子式 C15H14ClN3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9-Chloro-5-propyl-5,11-dihydro-6H-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one

参考文献

1. Schnapp G, et al. Commun Chem. 2020 Jun 10;3(1):75.

2. Arkelius K, et al. Circ Res. 2024 Apr 12;134(8):954-969.

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