DS-1040 tosylate hydrate |CAS:1335138-90-3 Probechem Biochemicals

Chemical Structure : DS-1040 tosylate hydrate

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DS-1040 tosylate hydrate (DS 1040;DS1040)

货号: PC-61011Not For Human Use, Lab Use Only.

DS-1040 tosylate hydrate (DS1040) is a small molecule inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50 of 1.7 ng/mL for rabbit TAFIa.

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DS-1040 tosylate hydrate (DS1040) is a small molecule inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50 of 1.7 ng/mL for rabbit TAFIa; a novel fibrinolysis-enhancing agent has favorable pharmacokinetic/pharmacodynamic properties and a favorable safety profile

Stroke

Phase 2 Clinical

物理化学性质&存储条件

分子量	483.624
分子式	C23H37N3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-amino-2-((1-((1r,4S)-4-methylcyclohexyl)-1H-imidazol-4-yl)methyl)pentanoic acid compound with 4-methylbenzenesulfonic acid (1:1) hydrate

参考文献

1. Zhou J, et al. J Thromb Haemost. 2017 May;15(5):961-971.

2. Gurewich V, et al. J Thromb Haemost. 2017 Oct;15(10):2080-2081.

3. Paul A Lapchak, et al. Abstract WP282: DS-1040 an Inhibitor of the Activated Thrombin Activatable Fibrinolysis Inhibitor Improves Behavior in Embolized Rabbits, Stroke. 2016;47:AWP282.

DS-1040 tosylate hydrate (DS 1040;DS1040)

生物&药学活性

物理化学性质&存储条件

参考文献

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DS-1040 tosylate hydrate (DS 1040;DS1040)

生物&药学活性

物理化学性质&存储条件

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