T-3364366 |CAS:1356354-09-0 Probechem Biochemicals

Chemical Structure : T-3364366

CAS No.: 1356354-09-0

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T-3364366 (T 3364366;T3364366)

货号: PC-61037Not For Human Use, Lab Use Only.

T-3364366 is a potent, selective and orally available inhibitor of delta-5 desaturase (D5D) with Ki of <2.7 nM and IC50 of 19 nM, with excellent selectivity over D6D and SCD.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2980	In stock
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100 mg		Get quote

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生物&药学活性

T-3364366 is a potent, selective and orally available inhibitor of delta-5 desaturase (D5D) with Ki of <2.7 nM and IC50 of 19 nM, with excellent selectivity over D6D and SCD.
T-3364366 potently inhibits arachidonic acid (AA) production in liver cell lines derived from human (HepG2) and rat (RLN-10) with IC50 of 1.9 and 2.1 nM, respectively.
T-3364366 exhibits a reversible, slow-binding interaction to the desaturase domain of D5D.

物理化学性质&存储条件

分子量	443.459
分子式	C18H16F3N3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((4-oxo-3-(4-(2,2,2-trifluoroethoxy)phenyl)-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl)thio)ethyl)acetamide

参考文献

1. Miyahisa I, et al. ACS Med Chem Lett. 2016 Aug 10;7(9):868-72.

T-3364366 (T 3364366;T3364366)

生物&药学活性

物理化学性质&存储条件

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T-3364366 (T 3364366;T3364366)

生物&药学活性

物理化学性质&存储条件

参考文献

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