Lapaquistat (TAK-475) | Squalene synthase inhibitor | Probechem Biochemicals

Chemical Structure : Lapaquistat

CAS No.: 189060-13-7

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Lapaquistat (TAK475, TAK-475, Lapaquistat acetate)

货号: PC-61039Not For Human Use, Lab Use Only.

Lapaquistat (TAK-475) is a novel potent, competitive, orally active squalene synthase inhibitor with IC50 of 78 nM.

规格	价格	库存
1 mg	￥1380	In stock
5 mg	￥2980	In stock
10 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Lapaquistat (TAK-475) is a novel potent, competitive, orally active squalene synthase inhibitor with IC50 of 78 nM.
Lapaquistat (TAK-475) displays no effect on plasma aspartate aminotransferase and alanine aminotransferase activities.
Lapaquistat (TAK-475) effectively inhibits cholesterol synthesis in rat liver with ED50 of 2.9 mg/kg (p.o.), lowers plasma total cholesterol, triglyceride and phospholipid levels in rabbits, also inhibits the secretion of cholesterol, triglyceride and phospholipid components of very-low-density lipoprotein (VLDL) from liver.

物理化学性质&存储条件

分子量	645.146
分子式	C33H41ClN2O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-{2-[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-1,2,3,5-tetrahydro-2-oxo-5-(2,3-dimethoxyphenyl)-4,1-benzoxazepine-3-yl] acetyl} piperidin-4-acetic acid

参考文献

1. Miki T, et al. J Med Chem. 2002 Sep 26;45(20):4571-80.

2. Amano Y, et al. Eur J Pharmacol. 2003 Apr 11;466(1-2):155-61.

3. Nishimoto T, et al. Br J Pharmacol. 2003 Jul;139(5):911-8.

4. Burnett JR. Curr Opin Investig Drugs. 2006 Sep;7(9):850-6.

Lapaquistat (TAK475, TAK-475, Lapaquistat acetate)

生物&药学活性

物理化学性质&存储条件

参考文献

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Lapaquistat (TAK475, TAK-475, Lapaquistat acetate)

生物&药学活性

物理化学性质&存储条件

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