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首页-小分子抑制剂&激动剂-Others-Other Targets-ORIC-533
ORIC-533

Chemical Structure : ORIC-533

CAS No.: 2641306-62-7

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ORIC-533 (ORIC533)

货号: PC-24616Not For Human Use, Lab Use Only.

ORIC-533 is a potent, selective, AMP-competitive and orally bioavailable ectonucleotidase CD73 inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ORIC-533 is a potent, selective, AMP-competitive and orally bioavailable ectonucleotidase CD73 inhibitor.
ORIC-533 decreases adenosine generation, overcomes immune suppression, and restores immune cell-mediated MM cell lysis.
ORIC-533 induces autologous MM cell killing in MM BM-MNCs in a dose-dependent manner.
ORIC-533 activates MM-BM pDCs in the MM bone marrow microenvironment.
ORIC-533 induces NK cell-mediated cytotoxicity in MM and enhances autologous MM cell killing in combination with Daratumumab.

物理化学性质&存储条件

分子量 605.93
分子式 C20H29ClN9O9P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 6-chloro-N-cyclopentyl-1-[5-O-[(1S)-1-(hydroxymethyl)-1-phosphono-2-(2H-tetrazol-5-ylmethoxy)ethyl]-β-D-ribofuranosyl]-

参考文献

1. Arghya Ray, et al. Blood Cancer J. 2024 Apr 9;14(1):58.

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