Rbin-1 (Ribozinoindole-1)

Chemical Structure : Rbin-1

CAS No.: 328023-11-6

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货号: PC-42264Not For Human Use, Lab Use Only.

Rbin-1 (Ribozinoindole-1) is a potent, specific and reversible inhibitor of eukaryotic ribosome biogenesis that targets the AAA+ protein Midasin (IC40=1 uM).

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Rbin-1 (Ribozinoindole-1) is a potent, specific and reversible inhibitor of eukaryotic ribosome biogenesis that targets the AAA+ protein Midasin (IC40=1 uM).
Rbin-1 inhibits the cell growth Wild-type fission yeast strains with GI50 of 136 nM, reduces the levels of Mdn1 in the Nsa1 particle.
Rbin-1 is a powerful probe for eukaryotic ribosome assembly.

物理化学性质&存储条件

分子量	256.3262
分子式	C13H12N4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	5H-1,2,4-Triazino[5,6-b]indole, 3-[(2-methyl-2-propen-1-yl)thio]-

参考文献

1. Kawashima SA, et al. Cell. 2016 Oct 6;167(2):512-524.e14.

2. Garbarino JE, et al. BMC Genomics. 2002;3:18.