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TN1

Chemical Structure : TN1

CAS No.: 289479-94-3

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TN1 (TN-1, HbF inducer TN1)

货号: PC-42268Not For Human Use, Lab Use Only.

TN1 is a potent, small molecule fetal hemoglobin (HbF) inducer with EC50 of 100 nM.

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10 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TN1 is a potent, small molecule fetal hemoglobin (HbF) inducer with EC50 of 100 nM.
At 100 nM, increases γ-globin expression (2.9- and 3.7-fold increase in KU812 cell and K562 cell, respectively) to higher levels than 50–100 uM hydroxyurea.
TN1 is a useful starting point for the generation of compounds that can be used for the treatment of SCD.

物理化学性质&存储条件

分子量 509.6021
分子式 C29H31N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Propynamide, N-[3-[[9-ethyl-2-[(trans-4-hydroxycyclohexyl)amino]-9H-purin-6-yl]amino]phenyl]-3-(4-methylphenyl)-

参考文献

1. Nam TG, et al. ChemMedChem. 2011 May 2;6(5):777-80.

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