PF-1355 (PF-06281355) | MPO inhibitor | Probechem Biochemicals

Chemical Structure : PF-1355

CAS No.: 1435467-38-1

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PF-1355 (PF06281355, PF1355, PF-06281355)

货号: PC-42279Not For Human Use, Lab Use Only.

PF-1355 (PF-06281355) is a potent, selective, orally active Myeloperoxidase (MPO) inhibitor with EC50 of 1.47 uM.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

PF-1355 (PF-06281355) is a potent, selective, orally active Myeloperoxidase (MPO) inhibitor with EC50 of 1.47 uM.
PF-1355 shows high selectivity over the closely related and clinically relevant thyroid peroxidase enzyme.
PF-1355 inhibits MPO activity in LPS-treated human blood with EC50 of 2.03 uM, blocks HOCl formation in biochemical and cellular assays.
PF-1355 completely blocks kidney injury acutely and prevented any progressive diseasw in anti-GBM glomerulonephritis.

物理化学性质&存储条件

分子量	321.3516
分子式	C14H15N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: 8.75 mg/mL
Chemical Name/SMILES	1(2H)-Pyrimidineacetamide, 6-(2,5-dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-

参考文献

1. Zheng W, et al. J Pharmacol Exp Ther. 2015 May;353(2):288-98.

PF-1355 (PF06281355, PF1355, PF-06281355)

生物&药学活性

物理化学性质&存储条件

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PF-1355 (PF06281355, PF1355, PF-06281355)

生物&药学活性

物理化学性质&存储条件

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