| Cat. No. |
Product Name |
Information |
| PC-27934 |
8015-P2
Mitofusin activator
|
8015-P2 is a potent and effective mitofusin activator with EC50 of 623 pM as fusogenic factor, allosterically activate mitofusins 1 and 2 (MFN1 and MFN2), demonstrates rapid reversal of sensory and motor neuron dysfunction in an Mfn2 T105M knock-in mouse model of Charcot-Marie-Tooth disease type 2 A (CMT2A). |
| PC-27933 |
StagX1
STAG2 inhibitor
|
StagX1 is a specific small molecule that inhibit the growth of Ewing sarcoma cells possessing mutant Stromal Antigen 2 (STAG2, SA2), selectively targets carboxylesterase 1 (CES1)-positive Ewing sarcoma cells. |
| PC-27922 |
KS79356
Kynureninase inhibitor
|
KS79356 is a potent small molecule inhibitor of Kynureninase (KYNU) with IC50 of 63.7 nM in cell-free kynureninase activity assays, displaying strong binding affinity (-7.8 kcal/mol), selectively suppresses proliferation of SUM159 (G50=233 nM) and MDA-MB-231 (GI50=450.8 nM) cells. |
| PC-27889 |
NE-2-6
TPO inhibitor
|
NE-2-6 is a potent, selective thyroid peroxidase (TPO) inhibitor with IC50 of 13 nM, shows 496-fold selectivity for TPO over MPO and 68-fold selectivity for TPO over LPO. |
| PC-27867 |
SPH7050
LANCL2 agonist
|
SPH7050 is a gut-restricted Lanthionine synthetase C-like protein 2 (LANCL2) agonist, binds LANCL2 with SPR KD of 2.73 uM, inhibits prostaglandin E2 (PGE2) production in bone marrow-derived macrophages (BMDMs) with IC50 of 0.85 uM. |
| PC-27863 |
AW-006
SNX10 modulator
|
AW-006 is a small-molecule modulator targeting Sorting nexin 10 (SNX10), selectively inhibiting osteoclast resorptive function while maintaining normal osteoclastogenesis in vitro. |
| PC-27847 |
L-Tetrahydro-2-furoic acid
PRODH inhibitor
|
L-tetrahydro-2-furoic acid (THFA) is a competitive inhibitor, reversible inhibitor of proline dehydrogenase (PRODH) with Ki of 0.2 mM for Escherichia coli proline utilization A (PutA) PRODH. |
| PC-27846 |
S-5-oxo
PRODH inhibitor
|
S-5-oxo (S-5-oxo-2-tetrahydrofurancarboxylic acid) is a competitive inhibitor, reversible inhibitor of proline dehydrogenase (PRODH), inhibits proline oxidation in mitochondria, induces selective mitochondrial decay of PRODH. |
| PC-27843 |
MBTP-15324
PRODH inhibitor
|
MBTP-15324 is an allosteric inhibitor of proline dehydrogenase (PRODH) with Kd of 1.45 uM, significantly attenuates cell viability, colony formation, and migration in PRODH-overexpressing lung cancer cells (A549 and LLC). |
| PC-27827 |
DD1E5
DDAH1 inhibitor
|
DD1E5 is a competitive inhibitor of dimethylarginine dimethylaminohydrolase1 (DDAH1) with Ki of 2.05 uM, inhibits cancer cell proliferation and a subsequent decrease in NO production with ADMA accumulation. |
| PC-27821 |
Caffeic acid phenethyl ester
Glyoxalase I inhibitor
|
Caffeic acid phenethyl ester (CAPE) is an active component of propolis and has an antiproliferative property in cancer cell lines via inhibition of NF-κB signaling, downregulation of inhibitor of apoptosis (IAP) family proteins, and modulation of the balance of Bcl-2 family members, inhibits human Glyoxalase I (hGLO I) with IC50 of 7.9 uM. |
| PC-27820 |
CAD-09
Glyoxalase I inhibitor
|
CAD-09 is a caffeic acid ester derivative and potently inhibitor of human Glyoxalase I (GLO I) with IC50 of 1.3 uM (human GLO I), shows significant antiproliferative effect on HL-60 cells. |
