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首页-小分子抑制剂&激动剂-Others-Other Targets-MDC134
MDC134

Chemical Structure : MDC134

CAS No.:

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MDC134 (MDC-134)

货号: PC-26793Not For Human Use, Lab Use Only.

MDC134 is a glucose-dependent insulinotropic small molecule that enhances β-cell insulin secretion in pancreatic β-cells through Ca2+ influx and cAMP-associated amplification.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MDC134 is a glucose-dependent insulinotropic small molecule that enhances insulin secretion in pancreatic β-cells through Ca2+ influx and cAMP-associated amplification.
    MDC134 enhanced insulin secretion in MIN6-K8 cells and isolated mouse islets under stimulatory glucose conditions.
    MDC134 increased intracellular Ca2+ levels, and nifedipine abolished its insulinotropic effect, indicating the involvement of voltage-dependent L-type Ca2+ channel-mediated Ca2+ influx.

    物理化学性质&存储条件

    分子量 437.54
    分子式 C25H31N3O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(cyclopropylmethyl)-3-methoxy-N-(1-(4-nitrophenethyl)piperidin-4-yl)benzamide

    参考文献

    1. Naoya Murao, et al. Biochem Biophys Res Commun. 2026 May 15:823:153962.

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