SGM-3 | Striga germination inhibitor, ShHTL7 inhibitor

Chemical Structure : SGM-3

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SGM-3 (Striga germination modulator-3)

货号: PC-27202Not For Human Use, Lab Use Only.

Striga germination modulator-3 (SGM-3) is a potent, selective germination inhibitor for Striga hermonthica, selectively binds to ShHTL7 and shows inhibitory activity against YLG hydrolysis by ShHTL7 with IC50 of 2.3 uM.

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生物&药学活性

Striga germination modulator-3 (SGM-3) is a potent, selective germination inhibitor for Striga hermonthica, selectively binds to ShHTL7 and shows inhibitory activity against YLG hydrolysis by ShHTL7 with IC50 of 2.3 uM.
SGM-3 is a ShHTL7-selective competitive inhibitor, weakly inhibits ShHTL2 (IC50=14.6 uM) and has no activities for other ShHTLs (IC50>50 uM).
SGM-3 inhibits the Striga germination induced by SPL7 that selectively binds to ShHTL7.
SGM-3 also suppresses Striga germination even when induced by GR24 that can be perceived by multiple ShHTLs.

物理化学性质&存储条件

分子量	391.45
分子式	C17H24F3N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3,5-trifluoro-6-(piperidin-1-yl)-4-((2-(piperidin-1-yl)ethyl)sulfonyl)pyridine

参考文献

1. Michio Kuruma, et al. Precis Chem. 2026 Feb 13;4(6):768-773.

SGM-3 (Striga germination modulator-3)

生物&药学活性

物理化学性质&存储条件

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SGM-3 (Striga germination modulator-3)

生物&药学活性

物理化学性质&存储条件

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